Botox with Antibiotics Confilcting Information

I have read on several sites that antibiotics interact with botox and on this forum it is said there is no reaction, I am confused.  <<URL link deleted, editor>>

Doctor Answers 3

Botulinu and Toxin (Dysport and Botox) and drug interactions including antibiotics

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There are certain antibiotics called aminoglycosides that can cause nerve damage such as gentamycin or streptomycin and for these reasons there combined interaction with Botulinum Toxin (Dysport and Botox) is generally discouraged. I am citing from the Botox package insert here: "Co-administration of BOTOX® Cosmetic and aminoglycosides1 or other agents interfering withneuromuscular transmission (e.g., curare-like nondepolarizing blockers, lincosamides, polymyxins, quinidine, magnesium sulfate, anticholinesterases, succinylcholine chloride) should only be performed with caution as the effect of the toxin may be potentiated."

I hope that definitively answers your question.

Chicago Plastic Surgeon
4.9 out of 5 stars 86 reviews

Botox is OK to use with most antibiotics, not aminoglycosides

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The majority of antibiotics used today can be safely consumed while patients undergo Botox treatment. There is a caution about using aminoglycoside antibiotics but these are rarely used.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews


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A certain class of antibiotics called the aminoglycosides, ( Tobramycin, Kanamycin, Streptmycin, can interfere with neuromuscular transmission. Since BOTOX essentially has the same action, the affect can be accumulate and create toxicity. There are some other medications which are reported to do the same thing: polymyxins, quinidine and a few others. 

  Be sure to tell your physician about any medications you might be taking.

Arnold R. Oppenheim, MD
Virginia Beach Dermatologist

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