First, let me start by saying that the FDA approved dose is 1 mg daily. So, any dose other than that is off label. For most males, using 1.25 mg five times per week is not too different than 1.25 mg daily. If you take 100 males using 1.25 mg daily and compare to 1.25 mg five times per week, I doubt you’ll see all that much of a difference after one year of use. Sure, there just might be a hint of better results with daily use but it will be a small difference. What we don’t know is if really there will be a difference after 10 or 15 years. Now that is a possibility … but we don’t know. Side effects will be fairly similar but of course the chances of side effects go up with any dose increase. But it’s a small chance of getting more side effects. Most males using 1.25 mg five times per week will have more or less the same chance of side effects as those using it daily. Together with your doctor, you can decide what feels right to you. Each jump in dose does come with a chance of better results but the jump has to be substantial in order to see those benefits. For example, 0.5 mg of final five times per week is not likely to help as much as 1.25 mg five times per week. It’s critically important to take note that as one goes up an up on the dose the chances of getting more and more benefits drop off. For example. 5 mg daily is probably better than 1 mg daily but only slightly. However, 1 mg daily is much better than 0.25 mg daily. Both are jumps of 5 times the dose. However, they don’t produce similar jumps in benefits.