Is it important for doctors to mix Sculptra two days before treatment to prevent lumps?

Question

I’ve read that it’s important to mix sculptra at least two days before treatment to prevent lumps. I’ve also learned some ‘world renowned’ docs who don’t mix early. I’ve heard it needs to be kept warm. What’s the truth here on mixing sculptra and preventing lumps? Also, how would one mix sculptra with prp? Thanks for taking the time to review and respond.

Anna Avaliani, MD · Answer

You have done a great amount of research, which is great.Some doctors have been reconstituting 72 horsing advance, others 48 ts, some 24 hrs and some immediately before injection. in 2022, FDA updated reconstitution requirements for Sculptra to add more cc of sterile water and gave clearance for the same day reconstitution and injection. I have never added PRP to Sculptra, so I will not be able to comment on how to best do it. I would inject Sculptra the way I normally do and then over the Sculpra inject PRP .
Hope this helps.Best, Dr.Anna Avaliani, NYC

Heidi C. Mangelsdorf, MD · Answer

Recently it has been shown that Sculptra may be mixed just prior to using or several days in advance. I do not mix Sculptra with PRP. PRP or growth factor serums are best used after microneedling.

Michael A. Persky, MD · Answer

Hello Hunt,

For many years it was recommended that Sculptra be mixed a few days before use.  Recent studies and research have shown that mixing Sculptra immediately before injection is also safe and in the studies did not prove to have increased complications including lumps and nodules.  I personally have been using Sculptra since 2009.  I prefer to mix it a few days and let it "marinate" before using.  We have not have any problems with lumps, bumps, or nodules using this technique.  PRP can be added to the syringe when injecting Sculptra.  As with any aesthetic procedure, be sure to choose your treating physician most carefully!  Good luck and be well.
Michael Persky, MD
Encino, CA
818 501-3223

Michael I. Echavez, MD · Answer

The company that makes Sculptra recommends mixing the product two hours before use.  Some physicians prefer to mix it sooner and the amount of time before treatment can vary from days to weeks.  To my knowledge, mixing Sculptra more than two hours before use has not been shown to decrease the formation of any possible lumps, but some physicians feel mixing it sooner leads to more ease of injection and less clogging.  Sculptra does not need to be kept warm but some physicians may prefer to do this.

Dmitriy Schwarzburg, MD · Answer

Sculptra is mixed at least 24 hours before use. Lumps can still form if Sculptra is injected incorrectly. Treatment - wise, remember to choose a board certified medical provider for your Sculptra injections.,

Is it important for doctors to mix Sculptra two days before treatment to prevent lumps?

Answers (5)