Can Laser Resurfacing and Wrinkle Fillers Be Combined?

Generally fillers are injected beneath the level at which lasers act.
You are correct that some lasers target water but not all. For example KTP lasers are targeted more for blood vessels. Other lasers are targeted for pigment in the skin (many of the hair or tattoo removal lasers).
So it really depends on which laser you are using.
Consult with your treating physcian and ask what the chromophore (target) is.
Even if the target is water there are no strict recommendations of which I am aware regarding hyaluronic fillers.
You may want to exercise caution in areas where the skin is thin and the restylane may be superficial (tear trough).
Please discuss with the individual performing the laser treatment.

Fractional laser is an amazing and highly effective treatment in our office. We use the laser treatment to help with acne scars, large pores, fine wrinkles, tissue collagen loss, scars, sebaceous hyperplasia, active acne, and for brightening dark pigmentation. Although there are very strong fractional lasers such as CO2 laser, we use lighter treatments for corrective skincare and maintenance of results. Our Thulium fractional laser, clear and brilliant laser, and Ultra Thulium laser are excellent options in our clinic. We also perform CO2 fractional and erbium depending on skin tone and tolerance for downtime. Patients do have to use a Melarase cream before and after treatment to help further reduce pigmentation after laser. Dark spots can improve with these treatments. I recommend fractional laser for incisional scars as well, especially after plastic surgery.

Best,
Dr. Karamanoukian
Realself100 Surgeon

We find them synergistic and like to laser first, get the collagen stimulated, and use fillers as a finishing element, similar to frosting on a cake and just refining the finished product.