Overreaction from Sculptra, Does That Mean You Got an Immune Disorder?

We the physicians don't have an answer to this question. We are still trying to figure it out. You will get many opinions but the truth is 'WE DONT KNOW'

Regards
Dr. J
Disclaimer: This answer is not intended to give a medical opinion and does not substitute for medical advice. The information presented in this posting is for patients’ education only. As always, I encourage you to see your personal physician for further evaluation of your individual case.

Sculptra acts as a biostimulant that creates collagen in the lower dermis, and the beneficial effects last 1-2 years. If injected in blobs or clumps (it is a viscous product that has some technique-related issues) nodules can result, but this is not an "auto-immune" response; this is what is intended with Sculptra use. Collagen formation is what provides the volume restoration intended with Sculptra use.

The same thing happens with Vicryl sutures, which are made of the same material as Sculptra (poly-L-lactic acid)--collagen replaces the suture as it dissolves, leaving the wound or incision line securely connected by new collagen formation that provides strength and cohesion to the scar.

If people didn't have a collagen response to Sculptra, it wouldn't "work," and if it didn't last long-term then it wouldn't be a satisfactory product to use for that indication. Shorter-term needs for filler are commonly achieved with HA (hyaluronic acid) filler such as Juvederm or Restylane.

Best wishes! Dr. Tholen

Typically an over-reaction to Sculptra result from the injection technique. The product is either injected in a clump, or too much is placed as a depot or the injection is placed in a troublesome area such as the lower eyelid or lips. It is far less likely that the reaction is related to an immune system problem. If you do have other concerns about your immune system you should check in with your primary care physician. I hope this information is helpful.