There are no side effects from glutathione IV injections if they are administered correctly. Because glutathione helps the body detox some patients may experience flu-like symptoms following a treatment. You should drink lot of water and take a hot bath if these symptoms occur and they should go away after a few hours. Glutathione is poorly absorbed orally when taken by mouth, therefore, intravenous therapy is recommended when treating medical conditions. IV glutathione is safe and should only be administered by a license medical professional. The skin effects of IV glutathione vary from person to person. The number of treatments needed to see improvement in skin texture and tone range from 15 to 30 treatments. It can take up to six months to see the benefits of IV glutathione combined with IV vitamin C and the results vary for each individual. The effects are not permanent since the skin is constantly changing and aging. IV glutathione for skin brightening is a off label use of glutathione and it is used to improve many medical illnesses. The dose may range from 1000mg to 5000mg per treatment combined with IV vitamin C. Glutathione appears to work by ridding the body of toxins and free radicals that lead to hyper-pigmentation, age spots, sun spots, wrinkles, fine lines and conditions such as melasma or post inflammatory hyper-pigmentation. It can help with cystic acne, acne-prone skin, red spots and skin roughness while improving the overall texture, tone, elasticity and smoothness of the skin.