Has anyone tried to use Latisse to diminish the fat bulging in the undereye area? Are there potential negative side effects?

No, this is unlikely to give improvement. A combination approach will give the most improvement. Fillers, lasers, and microneedling/PRP can improve under the eyes. My patients try to get non surgical treatments to avoid surgery. We use PRP and stem cells there often. I suggest consulting with an expert to develop a treatment plan best suited for your short and long term goals. Best, Dr. Emer

Latisse does not have FDA approval for topical fat loss; any such use will be "off label". There are safer options to treat the area.

Latisse should only be used as it is clinically indicated- for use on the upper lash line to achieve longer, fuller, darker lashes as Latisse affects the growth stage of hair follicles. If you have concerns of fat pockets in your orbital area, there are many other treatments available to address those concerns ranging from derma fillers, fat excisions, lasers, etc.