Doctors often refer to the dryness that occurs with isotretinoin and retinoids like Retin-A as the retinoid reaction. Although normal, the dryness can lead to a feeling of discomfort that can ultimately compromise your compliance. Retinoid reaction includes: DrynessRednessItchingBurningDiscomfortIn my office in Beverly Hills, I prescribe Accutane quite a bit for cystic acne and inflammatory scarring. Patients are advised to moisturize frequently with a non-oily moisturizer such as Elevase Moisture Booster, which we use in our office. Applied liberally on the face, the ceramides are soothing and relieve discomfort when possible. Best, Dr. Karamanoukian Realself100 Surgeon