Hello, Thank you for your question. When considering lipoma removal, it's important to take into account your overall health and any other medical conditions you may have, including swollen lymph nodes and a venous malformation. Swollen lymph nodes can be a sign of infection or other underlying conditions that might need to be addressed before undergoing any surgical procedure. It’s crucial to have a thorough evaluation by your primary care physician or a specialist to determine the cause of the swollen lymph nodes and ensure it is safe to proceed with the lipoma removal. Similarly, the presence of a venous malformation on your hand could potentially complicate surgical procedures. Your healthcare provider will need to assess the risks and benefits in your specific case. In summary, while it is generally possible to remove lipomas, given your current health issues, I strongly recommend consulting with your healthcare provider to evaluate your condition and determine the best course of action. They may perform additional tests or refer you to a specialist to ensure that it is safe to proceed with the surgery.