Are there any precautions or contraindications to consider when using hydroquinone?

Question

Anna Chacon, MD, FAAD · Answer

Hydroquinone is a very effective topical treatment for hyperpigmentation, but it does come with some important precautions to keep in mind to ensure safety and the best results.

Precautions:

Sun protection is essential: Hydroquinone can make your skin more sensitive to sunlight. Daily use of broad-spectrum sunscreen is crucial to prevent worsening pigmentation.

Limit duration of use: Typically, hydroquinone is recommended for short-term courses (often up to 3–4 months), as prolonged use can sometimes lead to irritation or, rarely, a condition called ochronosis (bluish-black darkening).

Patch testing: Especially if you have sensitive skin, it’s helpful to test a small area first to check for irritation or allergic reaction.

Avoid harsh products: Avoid combining hydroquinone with abrasive scrubs, strong acids, or other irritating skin treatments unless guided by a dermatologist.

Contraindications:

Pregnancy and breastfeeding: Hydroquinone is generally not recommended during pregnancy or while breastfeeding.

Broken or inflamed skin: Do not apply on active infections, eczema flare-ups, or open wounds.

Allergy to hydroquinone: Anyone with a known sensitivity to hydroquinone should avoid it.

With careful use — correct concentration, limited duration, and diligent sun protection — hydroquinone can be very effective and safe. It’s all about respecting your skin’s limits while targeting pigmentation.

Raffy Karamanoukian, MD, FACS · Answer

We have seen an influx of online ads that are promoting high dose prescription Hydroquinone delivered to your home. I would suggest not getting these formulas for longterm use as most derms will agree that hydroquinone holidays and breaks are a good option. I personally would alternate between HQ and Arbutin. Our skin lightener of choice is Melarase PM with Arbutin which is a good option for skin lightening.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Best, 
Dr. Karamanoukian
Realself100 Surgeon

Are there any precautions or contraindications to consider when using hydroquinone?

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