Sorry to hear about your ITP diagnosis. At our clinic, we've done thousands of PRP procedures. More importantly, we use a hematology analyzer to check the platelet count of the patient's blood at the beginning of the procedure, and the PRP that is produced just before we use it. If the platelet count is not high enough, we won't use the PRP, because it lacks enough of the active ingredient, the platelets and their growth factors and signalling proteins. Preparing good PRP is a delicate process, especially when the starting count is low (i.e. less than 200k/µL). It's very easy to lose all the platelets. It could still be possible to prepare good PRP from low platelet counts, but we often need to start with a much larger blood sample, adjust the settings of the centrifuge, do double-spin process, and carefully check the platelet concentration along the way to be sure that the PRP has the right concentration and dose for the purpose it's being used for. Even by itself, microneedling will rejuvenate the skin and stimulate collagen. I wouldn't add the PRP unless the concentration is tested and known during the procedure.Best wishes, Patrick Yam MD PRP Medical Aesthetics