Perlane Vs Juvederm Ultra Plus - Best Filler for Nasolabial Folds?

Perlane and Juvederm Ultra Plus are competitors and are designed to be an alternative to Retylane and Juvderm Ultra. They are all hyaluronic acid fillers, and so are not permanent, but both Perlane and Juvederm Ultra Plus are a bit thicker (more dense) so they last longer. In my experience, you can expect each to last anywhere from 9 to 12 months. I don't think there is a significant difference in terms of how long they last. What is more important is the technique of injection: if it is injected too deep, you will not really see much of a difference. If it is injected too shallow, then you may see some bumpiness or even some changes in the color of the overlying skin. So this is what I would recommend to you:
1) Either product will work well, as long as your injector is experienced
2) Ask to see some before and after photos of patients that the doctor has injected in the past
3) This area tends to be uncomfortable without some sort of anesthetic, either topical or an injection (I usually will numb the whole area well so that I can really mold the product into place once I inject it, so the patient will not be uncomfortable)
4) Don't be surprised if you need 2 or 3 syringes to get the desired effect, in particular if you have very deep folds
Hope that helps!
Dr. S

I recommend fillers to soften the nasolabial folds themselves and also lift around the mouth and cheeks to build underlying anatomical support. In our practice we combine Sculptra with other fillers "layered" on top and lasers, skin tightening treatments such as Thermage, Fractora, and Renuvion (J Plasma), thread lifting, and peels to get the most conservative, natural look. I suggest seeing a facial sculpting expert for a formal consultation. Best, Dr. Emer

Thank you for your question. They are both nice products with good longevity. Most times when nasolabial lines become deep it is a downstream effect from volume loss to the cheeks. The lack of support from above causes a deepening of the Nasolabial fold.  Often it produces a nicer result to treat the cheek area first, providing support. That is often enough to help reduce the NLF folds, or at least decrease the amount of product needed to soften the folds. This provides a much more natural looking outcome.

I prefer Juvederm for the nasolabial folds.  In most cases, the cheaper Juvederm Ultra is good enough.  But with certain people with heavier smile lines, I will use the Ultra PlusThe reason why I prefer Juvederm to Perlane in this area is that I have found that it attracts more water (hydrophilic) and I need to use less product.  Therefore, it can be more cost effective for my patients.

Juvederm ultra plus and perlane are
very similar. They are both hyaluronic acid fillers, tend to last
approximately 9-12 months and provide more volume than regular juvderm and
restylane. Your provider may prefer one of another but what matters most
is their injection technique and proper placement for optimal results.

Both products are hyaluronic acids but both are thicker versions of the smaller sibling, Restylane vs. Juvederm Ultra, respectively.  For nasolabial folds, either one is fine and if you're under the age of 45 it probabaly doesn't matter too much.  Juvederm Ultra Plus will give you 9-12 months and Perlane 15-18 months but expect a touch up at 4 months to make it last the full time.