Paraphenylenediamine is a component of hair dye that is used in pretty much all dyes except bleached blond. It is essentially what gives hair color dyes blackness. Many dyes have it and a certain percentage of the population will develop an allergic contact dermatitis to it. Allergic contact dermatitis becomes more severe with exposure. So every time you have your hair colored, you body remembers it has an allergy to the hair dye and reacts faster and stronger causing a more extensive rash with itching and swelling. The thinnest tissues of the face, like eyelids and ears react first. However, Restylane and Juvederm do not contain paraphenylenediamine.
No it does not. You may be confusing paraphenylenediamine with BBDE or Butanediol Diglycidyl, which is a chemical that is used to enhance the cross-linking of the hyaluronic acid in Restylane and Juvederm. The two are not related. It sounds like you might be allergic to hair dyes, since people who are allergic to paraphenylenediamine usually are allergic to permanent hair dyes or the dyes in furs (forgive me PETA for even mentioning furs!). If you are significantly allergic to PPD you should also avoid sulfa drugs, be careful with antidiabetes drugs related to sulfonylurea, Benzocaine ( used frequently, including in our office as a topical anesthetic), Procaine ( an injectable anesthetic) and PABA sunscreens. You should also be aware that PPD can cross react to color film developer (is this used anymore?), epoxy resin (a hardener) stamp ink pads, and black rubber products. However, fortunately, you should be fine with Restylane and Juvederm.
