Does Juvederm or Restylane Have Paraphenylenedia in It

Doctor Answers 5


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No it does not. You may be confusing paraphenylenediamine with BBDE or Butanediol Diglycidyl, which is a chemical that is used to enhance the cross-linking of the hyaluronic acid in Restylane and Juvederm. The two are not related.

It sounds like you might be allergic to hair dyes, since people who are allergic to paraphenylenediamine usually are allergic to permanent hair dyes or the dyes in furs (forgive me PETA for even mentioning furs!). If you are significantly allergic to PPD you should also avoid sulfa drugs, be careful with antidiabetes drugs related to sulfonylurea, Benzocaine ( used frequently, including in our office as a topical anesthetic), Procaine ( an injectable anesthetic) and PABA sunscreens.

 You should also be aware that PPD can cross react to color film developer (is this used anymore?), epoxy resin (a hardener) stamp ink pads, and black rubber products.

However, fortunately, you should be fine with Restylane and Juvederm.

Virginia Beach Dermatologist

Juvederm and Restylane do not have paraphenylenediamine in them

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This chemical is known to be a strong allergen in some patients, possibly sensitized to it in the past by hair dye and other chemical products. Neither Juvederm nor Restylane, whether with or without the anesthetic, distributed here in the United States has paraphenylenediamine in them.  I have just checked with the medical offices with both Allergan and Medicis, the respective companies of Juvederm and Restylane, and they have checked their sources to confirm that this chemical is not found in them.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

Does Juvederm or Restylane Have Paraphenylenedia in It

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After reading both packaged labels - NO it does not contain this chemical. From MIAMI Dr. Darryl J. Blinski

Paraphenylenediamine is a component of hair dye that can cause contact dermatitis

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Paraphenylenediamine is a component of hair dye that is used in pretty much all dyes except bleached blond.  It is essentially what gives hair color dyes blackness.  Many dyes have it and a certain percentage of the population will develop an allergic contact dermatitis to it.

Allergic contact dermatitis becomes more severe with exposure.  So every time you have your hair colored, you body remembers it has an allergy to the hair dye and reacts faster and stronger causing a more extensive rash with itching and swelling.  The thinnest tissues of the face, like eyelids and ears react first.

However, Restylane and Juvederm do not contain paraphenylenediamine.

Emily Altman, MD
Short Hills Dermatologic Surgeon

Not according to the manufactures

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Paraphenylenedia is a dye that can cause dermatitis.  However this compound is not found in the filler products.  If you are experiencing an allergic type sensitivity to a filler, please report this to your doctor.  Allergy to a filler product although rare has been reported and is possible even if in the past you have not had a reaction.

Kenneth D. Steinsapir, MD
Beverly Hills Oculoplastic Surgeon
4.9 out of 5 stars 26 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.