Where does the material in Juvederm come from? I heard that it's natural - what is it made from?
Juvederm Ingredients - How is Juvederm Made?
Doctor Answers 8
Juvederm is made from hyaluronic acid
Juvederm is a dermal filler which is made of non-animal stabilized hyaluronic acid. Because hyaluronic acid occurs naturally in the body, no prior allergy test is needed. The product is injected into (or below the dermis) to provide desired augmentation.
Thanks for your question! Dr. Stephen Goldstein
Juvederm is good stuff!
Juvederm is a filler that will soften fine lines and wrinkles. It is made of Hyaluronic acid (HA). HA is a natural occuring component of your skin. 40% of your Dermis (the deep layer) is made from HA and the remainder is made from collagen.
HA can be derived from other animals (roosters, pigs) but these forms of HA have unique proteins that can make them more susceptible to an allergic reaction. Juvederm is made from a synthetic process using bacteria.
The bacteria are completely removed at the end of the process and their is no residual protein to cause the allergic reaction. Juvederm is treated by cross-linking. This process allows it to last longer than competing products.
Overall, I give Juvederm an A!
Juvederm: A natural component of the skin.
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Juvederm is hyaluronic acid
Juvederm is a syntetic hyaluronic acid. Hyaluronic acid is a sugar-water molecule that makes up the normal skin’s infrastructure, cushioning the collagen and providing support.
Juvederm is hyaluronic acid
Juvederm Ultra and Ultra Plus are non-animal derived hyaluronic acid (HA) fillers. Juvederm is produced from bacterial fermentation. Hyaluronic acid is identical across species, so no HA filler requires skin testing for allergy. Juvederm results last up to one year, as the filler is gradually broken down by your body. While FDA approved for filling lines around the mouth, it is often used "off-label" for lip enhancement, cheek lifting, and sunken areas under the eyes. Besides being versatile, Juvederm can be dissovled with an enzyme if the patient does not like the result.
Juvederm comes from strep
Juvederm is derived from a bacterial source, streptococcus equi. Don't worry this is a harmless bacteria species to start off with. It is then broken down so the hyaluronic acid part is extracted out. (Back in 1965, I was extracting lipopolysaccharides from E. Coli a truly dangerous bacteria, but the extract was harmless....though we never thought of injecting it into people!). This bacteria-derived hyaluronic acid is also a polysaccharide, a glorified sugar molecule.
Since hyaluronic acid has no tissue specific or species specific antigens (proteins that can cause a reaction) it is thought to be virtually impossible to develop an allergic reaction to Juvederm, Restylane, Captique or Hylaform. The latter isderived from rooster combs, and while it too has little tendency for an allergic reaction it seems to have fallen out of favor.
Each of the hyaluronic acid fillers have different chemical properties depending not on the molecule itself but on the method used when it was extracted. The difference in qualities include: gel hardness, flow, particle size, concentration of particles in the gel (this say separates Perlane from Restylane and Juvederm Ultra from Juvderm Ultra Plus... Perlane and Juvederm Ultra Plus having more particles), swelling or the resistance to dilution...this accounts for the difference in longevity between the products; solubility, and finally cross-linking. The Allergan people boast about the Hylacross technology of their product, Juvederm, which allows more cross-linking and smoothness.
Hopefully, this answers your excellent question.
From bacterial cultures
Juvederm is just one form of hyaluronic acid filler. Hyaluronic acid is naturally found in your body. Juvederm specifically is derived in the laboratory from bacterial cultures.
Juvederm is marketed in the US by Allergan. It is manufactured in France and is derived from Streptococcus bacteria. It is then highly purified. It is not derived in any way from cadaver or animal sources.
Its main component is cross-linked hyaluronic acid and is molecularly identical to the hyaluronic acid found naturally in the human body. This is the reason why allergic reactions are very rare, and why its effect is so long lived.