Juvederm Ingredients - How is Juvederm Made?

Where does the material in Juvederm come from? I heard that it's natural  - what is it made from?

Doctor Answers 10

Juvederm is made from hyaluronic acid

Juvederm is a dermal filler which is made of non-animal stabilized hyaluronic acid. Because hyaluronic acid occurs naturally in the body, no prior allergy test is needed. The product is injected into (or below the dermis) to provide desired augmentation.

Thanks for your question! Dr. Stephen Goldstein

Englewood Plastic Surgeon

Juvederm is good stuff!

Juvederm is a filler that will soften fine lines and wrinkles. It is made of Hyaluronic acid (HA). HA is a natural occuring component of your skin. 40% of your Dermis (the deep layer) is made from HA and the remainder is made from collagen.

HA can be derived from other animals (roosters, pigs) but these forms of HA have unique proteins that can make them more susceptible to an allergic reaction. Juvederm is made from a synthetic process using bacteria.

The bacteria are completely removed at the end of the process and their is no residual protein to cause the allergic reaction. Juvederm is treated by cross-linking. This process allows it to last longer than competing products.

Overall, I give Juvederm an A!

Robert M. Freund, MD
New York Plastic Surgeon
4.8 out of 5 stars 33 reviews

Juvederm: A natural component of the skin.

Juvederm is a gel with a smooth consistency that is made of hyaluronic acid. Hyaluronic acid is a naturally occurring substance in your skin that adds volume and hydration, and is quite effective in correcting lines and grooves. The hyaluronic acid in Juvederm is generated by bacterial cultures and is not animal derived. Because hyaluronic acid is a natural component of the skin, there are very few reactions to Juvederm injections.

George J. Beraka, MD (retired)
Manhattan Plastic Surgeon
4.8 out of 5 stars 9 reviews

Juvederm is hyaluronic acid

Juvederm is a syntetic hyaluronic acid. Hyaluronic acid is a sugar-water molecule that makes up the normal skin’s infrastructure, cushioning the collagen and providing support.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 37 reviews

Juvederm is hyaluronic acid

Juvederm Ultra and Ultra Plus are non-animal derived hyaluronic acid (HA) fillers. Juvederm is produced from bacterial fermentation. Hyaluronic acid is identical across species, so no HA filler requires skin testing for allergy. Juvederm results last up to one year, as the filler is gradually broken down by your body. While FDA approved for filling lines around the mouth, it is often used "off-label" for lip enhancement, cheek lifting, and sunken areas under the eyes. Besides being versatile, Juvederm can be dissovled with an enzyme if the patient does not like the result.

Mary P. Lupo, MD
New Orleans Dermatologist
5.0 out of 5 stars 18 reviews

Juvéderm is made of hyaluronic acid

Juvéderm is safe and effective and is made of non-animal stabilized hyaluronic acid made in laboratories from bacterial cultures. Hyaluronic acid is a naturally occurring substance in human skin. The Juvéderm product line is well-known for its smooth consistency that results in a natural feeling and look.

Cory Torgerson, MD, PhD, FRCSC
Toronto Facial Plastic Surgeon
4.8 out of 5 stars 148 reviews

Juvederm and Ingredients

Juvederm is comprised of Hyaluronic acid which is a natural ingredient in the skin. Since Juvederm occurs naturally in the body there is a very rare incidence of allergy to the product and there is no skin test required unlike past fillers such as collagen or newer ones such as Bellafill. Juvederm is made in the laboratory from bacterial cultures and is not an animal based hyaluronic acid. Juvederm is composed of a gel which can be molded for various areas of the face to plump wrinkles and fill hollows.  Juvederm Voluma is one of the best fillers for the mid-face to give an immediate lift to the face and cheek area.  Juvederm Volbella is used for the fine lines around the mouth for wrinkles.  Juvederm Ultra plus is a great product for wrinkles in the nasolabial lines and to plump up the lifts.  The key is to consult a board certified dermatologist who is an expert in cosmetic injections for the best results.  Best, Dr. Green

Michele S. Green, MD
New York Dermatologist
5.0 out of 5 stars 76 reviews

Juvederm comes from strep

Juvederm is derived from a bacterial source, streptococcus equi. Don't worry this is a harmless bacteria species to start off with. It is then broken down so the hyaluronic acid part is extracted out. (Back in 1965, I was extracting lipopolysaccharides from E. Coli a truly dangerous bacteria, but the extract was harmless....though we never thought of injecting it into people!). This bacteria-derived hyaluronic acid is also a polysaccharide, a glorified sugar molecule.

Since hyaluronic acid has no tissue specific or species specific antigens (proteins that can cause a reaction) it is thought to be virtually impossible to develop an allergic reaction to Juvederm, Restylane, Captique or Hylaform. The latter isderived from rooster combs, and while it too has little tendency for an allergic reaction it seems to have fallen out of favor.

Each of the hyaluronic acid fillers have different chemical properties depending not on the molecule itself but on the method used when it was extracted. The difference in qualities include: gel hardness, flow, particle size, concentration of particles in the gel (this say separates Perlane from Restylane and Juvederm Ultra from Juvderm Ultra Plus... Perlane and Juvederm Ultra Plus having more particles), swelling or the resistance to dilution...this accounts for the difference in longevity between the products; solubility, and finally cross-linking. The Allergan people boast about the Hylacross technology of their product, Juvederm, which allows more cross-linking and smoothness.

Hopefully, this answers your excellent question.

Arnold R. Oppenheim, MD
Virginia Beach Dermatologist
4.7 out of 5 stars 14 reviews

From bacterial cultures

Juvederm is just one form of hyaluronic acid filler. Hyaluronic acid  is naturally found in your body.  Juvederm specifically is derived in the laboratory from bacterial cultures.

Steven Wallach, MD
New York Plastic Surgeon
4.1 out of 5 stars 29 reviews


Juvederm is marketed in the US by Allergan. It is manufactured in France and is derived from Streptococcus bacteria. It is then highly purified. It is not derived in any way from cadaver or animal sources.

Its main component is cross-linked hyaluronic acid and is molecularly identical to the hyaluronic acid found naturally in the human body. This is the reason why allergic reactions are very rare, and why its effect is so long lived.

Wilfred Brown, MD
New York Plastic Surgeon
4.7 out of 5 stars 13 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.