Can hyaluronidase be injected to try and remove filler if the Filler is not Hyaluronic Acid?

The concern is that hyaluronidase will only break down hyaluronic acid. If injected directly into deposits of hyaluronic acid at a reasonable dose, there is very little risk of removing your native hyaluronic acid. If alot of hyaluronidase is injected into an area that only contains your natural hyaluronic acid (no hyaluronic acid based filler) then there is a risk of creating a hollow or contour deformity. The same thing can happen when excess hyaluronidase is used in the face - it can remove some of your natural hyaluronic acid and create a hollow area. I hope this information is helpful for you.Stephen Weber MD, FACSDenver Facial Plastic Surgeon 

Thank you for your question.Hyaluronidase is used to dissolve only hyaluronic acid (HA) base fillers such as Juvederm, Perlane and Restylane. Contact the provider who injected you to find out exactly what kind of product was used. It is not recommended to inject using hyaluronidase unless you know a HA based filler was used. To be sure what is the best option for you, see two or more board-certified providers in your area for a complete evaluation to make sure you are a good candidate and that it is safe for you to have treatment.I hope this helps.

It is not recommended to inject your buttocks with hyaluronidase if you do not know what the original product is. You should go back to your original injector and confirm what the material was before proceeding with a treatment to resolve your concern. However, if it was indeed hyaluronic acid filler, then your body will naturally break it down so if you wait eventually the result will go away.

Hyaluronidase works to break down hyaluronic acid
based fillers. If it is not a hyaluronic acid filler, such as Radiesse, then
hyaluronidase will not be effective in removing the product. Unfortunately, the
only way to get rid of any non-hyaluronic acid filler is to wait until your
body has completely metabolized and dissolved the product. 

Injecting this enzyme to areas where HA has not been injected can result in depressions in the skin and is not advisable. Why are you not happy? Are you having lumps or redness?  If so, it might be highly advisable to have a biopsy to see what filler was used and what kind of reaction is occurring.  Patients gave been injected in this area with adulterated filler, even oils that have no business being injected anywhere in the body, and have developed TB of the skin and other ptoblems.  Please see a board-certified detmstologist or plastic surgeon for advice.