Will Hyaluronidase Dissolve Radiesse.

Doctor Answers 11

Hyaluronidase will not dissolve Radiesse

Hyaluronidase will not dissolve Radiesse.  There is no dissolving agent for Radiesse.  Nodules from Radiesse can sometime be broken up with a different fluid.  I like to use a steroid with 5FU or a steroid water to break up nodules. 

New York Oculoplastic Surgeon
4.7 out of 5 stars 65 reviews

Hyaluronidase Does NOT Dissolve Radiesse

The suffix -ase is used to name enzymes which break down SPECIFIC substrates. As such, Hyaluronidase will ONLY bread down Hyaluronic acid. This ability is a great plus in the use of these fillers (Restylane, Perlane, Juvederm) - if you do not like them, you can make them go away. There is NO enzyme which breaks down Radiesse. You will have to wait it out.

Dr. Peter A Aldea

Peter A. Aldea, MD
Memphis Plastic Surgeon
4.9 out of 5 stars 103 reviews

Hyaluronidase will not dissolve Radiesse

No, if you want to dissolve a hyaluronic acid filler with hyaluronidase, the enzyme will remove the filler.  Hyaluronic acid fillers are Juvederm Ultra and Ultraplus, Restylane and Perlane, Prevelle and some from overseas that are not FDA approved in the United States.  Radiesse is calcium hydroxyapatite and as there is no hyaluroinic acid in it, the enzyme will not break it down.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 37 reviews

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Hyaluronidase Not Effective for Radiesse

Hyaluronidase is an enzyme that specifically breaks down Hyaluronic Acid, and is therefore very safe and effective in reversing the effects of fillers such as Juvederm or Restylane.  Radiesse is Calcium Hydroxyapatite, a completely different compound, and Hyaluronidase will have no effect.

Jeffrey C. Poole, MD
Metairie Dermatologic Surgeon
5.0 out of 5 stars 6 reviews

Hyaluronidase only dissolves hyaluronic acid

Hyaluronidase is used to dissolve fillers such as Perlane, Restylane and Juvederm.  Any other non-hyaluronic acid fillers will be unaffected by hyaluronidase.

Carlos Wolf, MD
Miami Facial Plastic Surgeon
5.0 out of 5 stars 61 reviews

Radiesse cannot be dissolved by hyaluronidase

Unfortunately, hyaluronidase only dissolves hyaluronic acid based fillers such as Restylane, Perlane and Juvederm.  There is currently no agent that helps to dissolve or reverse the effects of Radiesse - only time.  Since Radiesse is not reversible and typically lasts longer than hyaluronic acid fillers, it is important to have the injections performed by an experienced, skilled physician.

Alison Stallings, MD
Tarrytown Dermatologic Surgeon


Hyaluronidase injections should have no effect on Radiesse.We have nothing available ,yet, that reverses the Radiesse fullness. Hyaluronidase works on Hyaluronic acid-based fillers, such as Restylane & Juvederm ,for example.

Khaled El-Hoshy, MD
Detroit Dermatologic Surgeon

Hyaluronidase will not dissolve Radiesse.

  No, hyaluronidase dissolves Restylane, Juvederm and Perlane which are all hualuronic acid based soft tissue fillers.  Radiesse is Calcium hydroxyapetite as will be unaffected by the hyaluronidase.  It's best just to let these fillers dissolve and go away by themselves, IMHO...and then seek out an MD who's aesthetics judgement suits your particular needs.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Hyaluronidase dissolves hyaluronic acid dermal fillers

Radiesse is made of calcium hydroxylapatite crystals suspended in a carrier gel.  Some common hyaluronic acid gel fillers include Restylane, Perlane and Juvederm.  Hyaluronidase dissolves hyaluronic acid based fillers.

Emily Altman, MD
Short Hills Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Radiesse Cannot be Reversed

Radiesse is comprised of calcium-based microspheres suspended in a water-based gel. Radiesse is not a filler but a stimulator of your own collagen which then acts to volumize tissue in a gradual, progressive, and predictable manner. Because it does not contain hyaluronic acid, Radiesse cannot be reversed with hyaluronidase. However, Radiesse is often a better, longer lasting procedure for volume replacement than hyaluronic acid-containing fillers. Volume replacement is now the most widely used nonsurgical cosmetic treatment for the correction of contour deficiencies and wrinkles of the face without the risk, recovery time, and expense of major surgery. Since Radiesse is not reversible, it is especially important to remember that the experience and technique of the physician injecting Radiesse is the most critical part to your achieving a beautiful, natural result. Please follow the video link below to see me injecting my wife with Radiesse into the lower cheeks, marionette lines, and jaw line! The web reference link below will take you to her one year and four year follow up pictures to see how effective and long-lasting these fillers can be!

Mitchell Schwartz, MD
South Burlington Dermatologic Surgeon
4.6 out of 5 stars 11 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.