Is the Collagen Induced by Radiesse and Sculptra Permanent?

Radiesse and Sculptra work by stimulating the body's collagen. Sculptra relies mostly on the body to produce collagen while radiesse provide an initial scaffolding from calium but slowly absorbs it. While the absorption process takes place, collagen is deposited around it. Both of these products will result in more collagen to be produced in the injected area. Is this newly made collagen permanent? If not, why? How does the new collagen differ than unstimulated collagen?

Doctor Answers 3

Collagen induced by Sculptra and Radiesse is temporary

 No, the collagen induced by fillers like Sculptra and Radiesse are temporary and would not be permanent or these fillers would be classed with silicone, Artefil and other PMMA fillers in the permanent category.  I would guess that the collagen stimulation continues as long as something in the fillers remains to stimulate its formation.   (Radiesse ~ 12 and 24 months for Sculptra).

Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Radiesse and Sculptra are Similar Treatments and are not Permanent

It is important to understand the difference between "stimulatory" fillers and "wrinkle" fillers.  When treating problems due to volume loss such as cheek hollows and sagging skin beside the mouth, I will almost always use stimulatory fillers such as Radiesse and/or Sculptra. They are injected deeper, beneath the skin, and will generate more volume to create a much better lifting effect for sagging skin. Radiesse and Sculptra both work in a similar fashion They work by stimulating your skin to produce more collagen, which is why they are so effective, and give longer-lasting results too. However, the results are never permanent as this new collagen is gradually reabsorbed over many years. There is very little difference between this newly stimulated collagen and your regular collagen.


Mitchell Schwartz, MD
South Burlington Dermatologic Surgeon
4.7 out of 5 stars 12 reviews

Radiesse and Sculptra allow the body to make more collagen

There is long term persistence of the new collagen that is formed after fillers and volumizers.  The volume is not enough to fill areas or revolumize areas without additional product / filler when it clinically wears off in a year or two, such as with Radiesse or Sculptra.  Histology of biopsies does show that there is more collagen produced in the dermis even after Restylane and Juvederm. This natural collagen response would be seen microscopically years later but again, not enough to preclude the need for further fillers in the future.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 37 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.