Thank you for your question. With respect to your treatment options - these are broadly non-surgical and surgical. Non-surgical treatments tend to be temporary and do not replace the lost hair. They may increase the hair thickness and overall quality. Some of these treatments may cause more hair growth overall but on stopping the treatments, what has grown will shed. Surgery offers a permanent solution because the hair is taken from the back of the scalp - this area never loses hair as the receptors on the hair follicles are different to those on the top of your head. So when this hair is transplanted, then it does not shed. If you have existing hair on your scalp, depending on your age, they may still shed so timing might be an issue in terms if when you should get the transplant done. Having the transplant will not prevent your existing hairs from shedding eventually. If your scalp has been relatively stable over the last few years then chances are you might not shed any more. But it really depends on your age and the time you started to develop MPB. In terms of the number of grafts, 4000 grafts is possible but there are certain issues to bear in mind. Using FUT to attain this quantity will mean a wide area of your scalp to be removed. This scar, depending on your laxity will have a higher propensity to stretch as it will be under greater tension. Using FUE, and individually removing each hair also has its disadvantages for that quantity as this can leave a very sparse looking donor site. We carry out both methods in our clinic. The main issue is to make sure you get adequate density. It is better to concentrate on either the front or the back and develop a thick head of hair then spread it over the entire area and have a thinning look to your transplant. Most hairs will have grown through by 2 years and at this stage if you feel it is thin then another transplant can be carried out. My biggest concern with taking such a large number in one sitting is the effect it will have on the subsequent scar. We get very good results with 2500 hairs and the scar on the scalp tends to be quite hidden and not stretched. When you increase the graft quantity, you increase the overall width of the scar. This is where tension on the scar ends becomes an issue. What you dont want to end up with is more hair on top and then a strip of no hair from the donor site. I hope this helps with your question Kind regards