To be honest with you, there is no big difference between the two. If your cup size is a C or above, then the difference can be unperceivable. This is why you might not see them used very often. Safety is not an issue. I will caution you, however, against choosing a large implant. Breast implants weigh considerably and can cause a myriad of problems down the line. They may look great initially, but can stretch tissue, cause chronic pain, extrude, cause capsular contractures, etc. Please choose the smallest implant that will give you the 'look' you want to minimize future complications. Visit the breast implant revision forum on this site for more information on the subject. I hope this helps.Kind regards,Gary Horndeski M.D.