My Dr. has been diluting & injecting Sculptra within minutes?

Following up my earlier post... Turns out when i asked him whether he prepared the Sculptra 72h beforehand, he said "No, i dilute a few minutes before injection. It's ok because i use a 'shaker' " So it seems i have been improperly treated w Sculptra for several yrs by this guy. He dilutes and injects in both cheeks, all within 15 minutes or so. I'm lodging a complaint. What would be the downside, in terms of results, from this incorrect treatment? Thanks for any information.

Doctor Answers 9

My Dr. has been diluting & injecting Sculptra within minutes?

Thank you for your question. Sculptra should be diluted at least 24 hours before injection. The

problem with diluting it minutes before injection is that it can lead to lumps and nodules. Sculptra is a great product to correct shallow to deep facial wrinkles and folds. It also helps to replace lost collagen.


Summit Emergency Medicine Physician
5.0 out of 5 stars 22 reviews

Does Sculptra need to be reconstituted before treatment?

Sculptra injectable comes to the physician in a powder- wafer form and does need to be hydrated/reconstituted prior to use. We do this several days prior and have found this reduces the clogging issues compared to hydrating this within a few hours. Different injector providers may have slightly different timetable experiences. Sculptra of course works to stimulate one’s own collagen over time, so an understanding of realistic response timetables is also important. 

Donn R. Chatham, MD
Louisville Facial Plastic Surgeon
5.0 out of 5 stars 62 reviews

My Dr. has been diluting & injecting Sculptra within minutes?

Sculptra should be reconstituted a minimum of two hours but up to several days prior to treatment. Some injectors may not want to do this too early if they are afraid they will not have the volume of business that may leave the Sculptra going unused and wasted. Sculptra requires an experienced injector for best results - a board certified derm or plastic surgeon is your best bet for this treatment. Good luck. 

Richard Zienowicz, MD
Providence Plastic Surgeon
4.8 out of 5 stars 45 reviews

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Mixing Sculptra before procedure

We always have pre-mixed Sculptra vials ready for treatment that have been reconstituted days earlier, as we inject Sculptra daily so it is important to have some available at all times. The teaching has always been to mix it at least a day or two in advance of treatment. However, I'm not sure of any studies or data to indicate that this is truly necessary and prevents nodules or bumps. That said, since the company does recommend this, I feel that it makes sense to follow their guidelines.  

Ryan Greene, MD, PhD
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Sculptra Technique

I always reconstitute Sculptra five days prior to visit as it is very viscous and needs time to settle naturally so as to avoid potential clogging which makes it difficult to properly inject and could lead to potential lumps or nodules. Scluptra is a brilliant product for the right candidate, however it is not an easy one to use which is why it is so important to seek out a board-certified dermatologist or plastic surgeon with extensive experience injecting Sculptra. 

Dennis Gross, MD
New York Dermatologist
4.4 out of 5 stars 5 reviews

Mixing Sculptra just before injections

The downside to this is that there is potential for clumping of the product which can lead to nodules. It is still as effective as it would be if mixed days before. The FDA approval is actually mixing it the day of the procedure.

Steven F. Weiner, MD
Panama City Facial Plastic Surgeon
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My Dr. has been diluting & injecting Sculptra within minutes?

Most experienced injectors reconstitute Sculptra a few days in advance. Maybe your doctor already reconstituted it and just dilutes it more just before injection.

Karol A. Gutowski, MD, FACS
Chicago Plastic Surgeon
4.9 out of 5 stars 65 reviews

Sculptra dilution....

Thank you for your question.  Sculptra should be diluted at least 24 hours ahead of injection to minimize lumps and bumps.  If you have not had any issues or side effects with his technique, then there has been no downside.  Most active Sculptra practices have 1 bottle always mixed, they don't mix specifically for a patient.  Additionally, dilution techniques vary and can range anywhere from around 7ml to upwards of 15ml per vial depending on practitioner and area being injected.  Regards, Dr. Matt Elias

Matthew Elias, DO, FAAD
Fort Lauderdale Dermatologic Surgeon
5.0 out of 5 stars 5 reviews

Sculptra preparation

Typically, the Sculptra needs to be reconstituted/diluted with bacteriostatic water and lidocaine. In our clinic, I reconstitute the Sculptra myself using 9 cc of bacteriostatic water. I then let the Sculptra sit in the fridge for at least 7 days making sure all of the PLLA particles are adequately hydrated. Before injection, I mix in an additional 1 cc of 2% lidocaine without epinephrine. The total dilution is 10 cc of diluent per vial of Sculptra. 

Adequate hydration of the PLLA particles in Sculptra is important to minimize the risk of lumps, bumps, and granulomas.

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.