Looking for insight on Allocae. How different is it from Renuva?

Question

I can’t find any information on the longevity of Allocae and also wanted to the know difference between Renuva. I’m looking to use it for an irregularity from a previous procedure.

Matthew J. Nykiel, MD · Answer

Thanks for the great question!

Fat transfer traditionally involves removing fat from one part of your body and injecting it into areas that need more volume—common examples include the face and buttocks. One of the key benefits of using your own fat is that it contains live stem cells, which may help improve skin texture and overall appearance.

However, not everyone has enough fat available for transfer. In these cases, we now have allograft fat options—donor fat from another individual. In the U.S., there are currently two main FDA-approved products:

1. Renuva
FDA Approved: 2021
Longevity: Reported to last up to 10 years
Processing: The fat is processed to retain the extracellular matrix (ECM)—a structural framework that supports fat regeneration—but does not contain live cells
Consistency: Very smooth, allowing for precise injection into facial or superficial fat layers
Volume: Comes in small syringes (3cc), making it ideal for smaller treatment areas like the face or hands

2. Alloclae
FDA Approved: 2025
Processing: Uses X-ray sterilization, preserving both the ECM and the cell wall - cellular components are removed, which may provide added regenerative benefits
Texture: Firmer than Renuva—designed for use in larger-volume body areas, not the face
Volume: Available in larger sizes (12.5cc and 25cc), making it more practical for body contouring
Longevity: Still being studied, but early expectations suggest similar duration to Renuva—however there is a difference in processing - so the longevity may be the same, worse, or better.

In summary:
If you have enough of your own fat, it’s usually preferred because of the added skin-rejuvenating benefits. But for patients without sufficient donor fat, Renuva and Alloclae offer exciting alternatives, each with unique advantages depending on the treatment area and goals.

Anna Chacon, MD, FAAD · Answer

Allocae and Renuva are both products used in cosmetic procedures to address volume loss and irregularities, but they have different compositions and mechanisms of action.

Allocae:

Composition: Allocae is a newer product, and specific detailed information about its formulation and longevity may be limited. It is important to consult with a provider who is experienced with this product for the most accurate and up-to-date information.
Use: Typically used in soft tissue augmentation, but specifics on its application and results may vary based on clinical use.
Renuva:

Composition: Renuva is an allograft adipose matrix, which means it is derived from human fat tissue. It serves as a scaffold that encourages the body to regenerate its own fat cells in the treated area.
Longevity: The effects of Renuva can be long-lasting, as it promotes natural tissue regeneration. However, results can vary depending on the area treated and individual patient factors.
Use: Often used to correct volume loss and contour irregularities, Renuva is popular for its natural-looking results.
Differences:

Material: The primary difference lies in their composition and how they interact with the body. Renuva uses an adipose matrix to stimulate natural fat growth, whereas Allocae's specific formulation and mechanism may differ.
Longevity and Results: Understanding the longevity and expected outcomes of Allocae might require direct consultation with a practitioner who uses the product, as it may not be as widely documented as Renuva.
For personalized advice and to determine which product might be more suitable for correcting an irregularity from a previous procedure, consulting with a board-certified dermatologist or plastic surgeon experienced with both products would be beneficial. They can provide insights based on the latest clinical data and their experience.

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