How does Ozempic work for weight loss? What is the science behind it?

Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 is a naturally occurring hormone that is released in the intestines in response to food intake. It plays a crucial role in regulating glucose metabolism by stimulating insulin secretion, inhibiting glucagon release (a hormone that raises blood sugar levels), and delaying gastric emptying.
Here's how Ozempic works for weight loss:
1. Appetite Regulation: GLP-1 receptor agonists like Ozempic can affect areas of the brain that control appetite and energy intake. By activating these receptors, Ozempic can help reduce hunger and increase feelings of fullness, leading to a decrease in caloric intake.
2. Slowing Gastric Emptying: GLP-1 slows the rate at which the stomach empties after eating. This can prolong the sense of fullness after a meal, which can help reduce food intake.
3. Blood Sugar Control: Ozempic also helps lower blood sugar levels by increasing insulin secretion (the hormone that reduces blood sugar) and reducing glucagon secretion.
While Ozempic is primarily used to manage type 2 diabetes, the effects on appetite and gastric emptying can lead to weight loss. It's worth noting that lifestyle changes, including a healthy diet and regular exercise, are also important when aiming for weight loss.

Semaglutide is almost identical to a natural peptide in the body that slows stomach emptying. It makes you feel full faster and longer. That sends a signal to your brain that you are full. Basically you will eat less because you are not as hungry, have less craving for food and many describe a decrease in food noise.