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I would have hoped your prescribing physician would have gone over all your medications, vitamins, and supplements with you before prescribing Accutane. Don't take your fish oil, or any other version of Vitamin A, while on Accutane, UNLESS it's just in a multivitamin formulation. It's absolutely not a good idea, and it's unnecessary. You can apply makeup as you would normally. If you take any other medications, supplements, or vitamins, please discuss them with your prescribing physician at your next visit. It's important!