Which Fillers Are Okay to Mix and Which Are Not?

Is it okay to mix lip fillers. ie: I had Perlane injected into my lips but would like a bit more fullness is it okay to get injected with Restalyne or Juvaderm the next time? What mixtures of fillers are not okay and which are?

Doctor Answers 9

Fillers and mixing

It is not like mixing drinks! Perlane, restylane, juvederm, etc. are all ok to use together. It should not be a problem. The results should be the same.

New York Plastic Surgeon
4.1 out of 5 stars 29 reviews

Using a combination of different fillers

Many physicians are finding that good aesthetic results are achieved by inserting thicker products deeper and thinner products more superficially right over the former. Some thinner products can be used in thin skinned areas while the thicker fillers shouldn't. One hestitancy about using multiple fillers, is that if there is a reaction, it might be difficult to discover which filler was responsible for the unwanted effect.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 37 reviews

Combining different facial fillers

Combining different types of fillers especially on the face is often effective and many times recommended. For example, if you have deep nasolabial folds, then a deeper filler like radiesse or perlane can be placed deeply followed by restylane or juvederm more superficially to improve the folds. In the lips, it is best to use the hyaluronic acid fillers like restylane or juvederm. I think perlane may be too thick and can lump up so you are fortunate it worked well for you. I hope this information helps.

Scott Trimas, MD
Jacksonville Facial Plastic Surgeon
5.0 out of 5 stars 20 reviews

Mixing Fillers

It is perfectly fine to mix fillers (Restylane and Juvederm are both HAs). It is not good to put Radiesse in the lips, but it is great for the cheeks. Good luck.

David Shafer, MD
New York Plastic Surgeon
4.9 out of 5 stars 75 reviews

Hyaluronic acid fillers okay to mix

It is perfectly safe to mix hyaluronic acid fillers, including Perlane, Restylane, Juvederm, and Prevelle. Fillers of differrent "thickness" are used in different areas of the face for a specific result, and may sometimes be layered on top of one another to achieve the desired effect.

Lips are a special place, and require specific fillers for optimal results (depending on the desired effect... volume, definition, etc.). I find Perlane a bit thick for lip volumization, and prefer Juvederm or Prevelle. However, Perlane is safe. I would not use Radiesse, Sculptra, or other type of non HA filler (except collagen) in the lips however... using these products in the lips is asking for trouble.

Chad L. Prather, MD
Baton Rouge Dermatologic Surgeon

Using different fillers on the same face

Most dermatologists will use different fillers for different locations within the same patient. For instance the lip area may be different than the nasolabial area. The fillers generally do not interact with each other.

Steven Hacker, MD
West Palm Beach Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Not many good reasons to mix fillers

Although there should be any major problems with combining hyaluronic acid (HA) fillers such as Restylane, Perlane, and Juvederm, there aren't usually any good reasons to do so either. If the goal is to provide volume at a deep level and layer a thinner filler more superficially, then Perlane/Restylane or Juvederm Ultra Plus/Juvederm Ultra would make sense. Technically this is layering rather than mixing.

Richard Baxter, MD
Seattle Plastic Surgeon
4.9 out of 5 stars 52 reviews

It is safe to mix Perlane with Restylane or Juvederm

It is usually safe to mix different hyaluronic acid fillers, for example, you will do well with either Restylane or Juvederm added to Perlane, if you have a good reason to switch. There are some fillers that should not be used in the lips, like Radiesse or Hydrelle. You should also know that all the fillers that we use in the lips are used off label, meaning that none of them are approved for this use, but they have a long history of being safe and effective.

Stella Desyatnikova, MD
Seattle Facial Plastic Surgeon
4.5 out of 5 stars 18 reviews

Sure, fillers mix

Personally I believe that some products are better for certain applications. Perlane can be used for the lip but it is not ideal for this location. Perlane is a great volumizer but it is difficult to manipulate once placed.

It does not hide well in locations like the lip edge or under eye hollows. For these applications I prefer Restylane. I am not a big fan of Juvederm for certain areas because it seems to drift a bit. However, others seem to love Juvederm. Nevertheless, absolutely these products can be layered into each other without a problem.

Kenneth D. Steinsapir, MD
Beverly Hills Oculoplastic Surgeon
4.9 out of 5 stars 26 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.