It is unlikely that smoking will affect the longevity of the filler product whether it is restylane or another HA.
Restylane is a very popular and effective hyaluronic acid-base dermal filler. It has been used widely throughout the face for the correction of deep lines and wrinkles. Although smoking will not directly affect the behavior of Restylane, it will affect the characteristics of your skin and make your overall skin treatment regimen less effective. If you are receiving Restylane and other skin treatments, do yourself a favor and stop smoking to optimize the appearance of your skin.