Does Juvederm Stimulate Collagen Growth?

Yes, Juvederm does stimulate collagen growth. There have been multiple studies proving that Juvederm does indeed stimulate collagen.  In addition, the hyaluronic acid in Juvederm acts like a sponge to absorb water.  This absorption of water leads to a plump filling of the injected wrinkled.

Although most long-time injectors as well as patients have believed that repeated use of cosmetic dermal fillers led to collagen stimulation -- it is now supported with research by both Allergan and Medicis. Many users will experience this by realizing that they need less product and may go longer between treatments. This concept of collagen stimulation is also true of many class IV medical lasers.

The other consultants have referenced the article, which suggests that Restylane induces the formation of collagen by causing swelling and subsequent recruitment of the cells responsible for collagen production. All of us who have been injecting hyaluronic acid products since they were released in 2000, have observed a "retention" of effect, especially in the lips, after repeated treatment. What is not clear is whether the collagen stimulated is Type I (desirable "de novo") or III (scar type) is unclear.
Sculptra maintains that the type of collagen induced by their product is type I, which would be extremely unique and thus a truly anti-aging modality. I don't know what subtype collagen is induced by Radiesse. However the most important consideration for me, as a plastic surgeon, who may offer surgery to a patient is whether these injectables will disqualify patients from future surgeries, if they desire them in the future. I have successfully performed facial surgery on patients who had previously used HAs, Sculptra and not encountered problems with wound healing.
Good luck.

Juvederm is a hyaluronic acid, much like Restylane. Restylane has been shown to stimulate collagen growth but not because of the actual filler, but because of the spreading of the collagen fibers induced by the injection into the skin. The fillers that clearly stimulate significant amounts of collagen are Radiesse and Sculptra.
To your health,Dr. David Goldberg

A nice article from 2007 showed that collagen is stimulated by injections of hyaluronic acid. Restylane and Juvederm should both stimulate collagen production.


1: Arch Dermatol. 2007 Feb;143(2):155-63. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ