Yes, but the answer is complicated. Invisalign is a product that is innovative and technically sophisticated with a certain aesthetic elegance, not unlike an iphone; therefore, many assume that Invisalign is similar to an iphone in that where it is acquired is unimportant. In reality, Invisalign is of greater similarity to a surgical robot or a Boeing aircraft—technically advanced, yet dependent upon the experience and judgment of the operator. However, given that Invisalign is a commercial product, developed and marketed directly to the public, and that the chance of morbidity is non-existent, the threshold of qualification to become an Invisalign provider has been loosely regulated. This is a complicating factor in Invisalign performance due to several issues. Firstly, the Invisalign technology has been marketed to both orthodontists and general dentists under the mistaken belief that the computer-programed Invisalign baseline is sufficiently sophisticated to produce satisfactory results in non-complex cases without significant doctor modification. This has not proven to be true. The Invisalign baseline considers only position of the dentition without reference to bone and soft tissue status and relationship, factors which greatly impact treatment planning and the sequencing of tooth movement. Secondly, the mechanics of the Invisalign system, i.e. the capacity for, and application of, force, are quite distinct from the edgewise/bracket-and-wire system; therefore, to effectively utilize Invisalign, the practitioner, whether orthodontist or general/aesthetic dentist, must make a significant educational investment in the use of this tool. Thirdly, a further complication for the non-orthodontist is that the ability to determine the relative complexity of an orthodontic case, as well as treatment plan for those that are complex, is developed not through education as a general/aesthetic dentist but through two to three years of post-doctorate education in orthodontics. (Even so, there do exist general/aesthetic practitioners who are capable of utilizing Invisalign responsibly and who are quick to refer those cases that present with complicating factors to an orthodontic specialist.)The fact that the question remains, “Does Invisalign work?” points to the issues discussed above and the resulting inconsistency in treatment outcome. A significant number of Invisalign cases have been and are attempted by those who do not have the adequate diagnostic skills, mechanical understanding, and/or experience to complete these treatments. However, when utilized by an orthodontic clinician who is both experienced in the specific biomechanics associated with Invisalign treatment and who has the diagnostic ability to recognize appropriate clinical indications, Invisalign is a very effective and reliable orthodontic modality.