Will enzymes that break down nutrients affect dermal filler by breaking down and the body metabolizing them faster?

No, most fillers used today are made of hyaluronic acids with different methods of cross linking affecting their viscosity and longevity. In FDA trials their safety and efficacy were tested as well as their longevity. The longevity is consistent over a wide range of patients. For most HA fillers you will get 12-24 months of duration.