Does exercise/lifting weights reduce effectiveness or longevity on Botox for underarm hyperhidrosis?

I have many patients in which the botox or other neurotoxin doesn't last as long in suppressing wrinkles on the face -- especially those patients who exercise a lot or are very expressive.  I have a few patients who have reported a similar effect in underarm, palm/sole, or back sweating.  These patients typically require higher doses to maintain another patients similar clinical effect.  It appears to me that when there is more neurological activity, the toxin is challenged and new or alternate connections are made to compensate.  This is not something that anyone should be concerned about, and is not something I hear often, but i thought it would be best to report.  I wish you the best of luck, Dr. Emer.

This is a good question.
There is potential that an increase in sweat may cause the Botox to wear off
faster, however, I do not believe that there would be a very significant change
in the length of time it would last. It is important for your overall health to
continue to exercise regularly, so I would not worry too much about this.

Botox and, now, Dysport for underarm hyperhidrosis are great options for reducing sweating.  If you are experiencing issues, consider this as the treatments last for up to 3-6 months and are a terrific choice.  I haven't ever heard of them being shorter due to exercise, which is a good thing!