Can hyaluronidase help to dissolve the fat more evenly & efficiently when combined with Kybella?

Question

I have gotten kybella at several different locations. Each time the practitioner injects a small amount of lidocaine mixed with hyaluronidase before injecting the kybella. I have never had filler in any areas near where I am receiving kybella. When I asked why hyaluronidase was used I was told it can help to dissolve the fat more evenly and efficiently when combined with kybella. Is this true?

Anil R. Shah, MD · Answer

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. Hyaluronidase and Kybella serve different purposes and are generally not combined in treatments for dissolving fat. Here's a brief overview of each and why combining them might not be effective or recommended:

Kybella: Kybella is an FDA-approved injectable treatment specifically designed to dissolve fat cells. It contains deoxycholic acid, which naturally occurs in the body and helps break down and absorb dietary fat. Kybella is primarily used to target submental fat (under the chin) and can also be used in other areas where localized fat reduction is desired. The fat cells are broken down and gradually eliminated by the body's lymphatic system.

Hyaluronidase: Hyaluronidase is an enzyme used to dissolve hyaluronic acid-based fillers. It works by breaking down hyaluronic acid, which is a common component of many dermal fillers. It does not have the same effect on fat cells or fatty tissue.

Combining Hyaluronidase with Kybella is not generally considered effective because:

Different Targets: Hyaluronidase targets hyaluronic acid, not fat. Kybella specifically targets fat cells, and the two substances do not interact with each other in a way that would enhance fat dissolution.

Lack of Synergy: There is no clinical evidence supporting the combined use of these two agents to achieve more even or efficient fat dissolution. Using hyaluronidase in an attempt to affect fat cells could lead to unpredictable results and might not address the intended treatment goals.

If you’re looking to achieve more even and efficient fat dissolution, it's best to use Kybella alone. I hope this helps and best of luck!

Can hyaluronidase help to dissolve the fat more evenly & efficiently when combined with Kybella?

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