Does 5-FU for scar tissue cause systemic effects?

5-Fluorouracil (5-FU) is a medication commonly used in dermatology for various purposes, including the treatment of certain scars. When used for scar management, 5-FU is typically injected directly into the scar tissue, which is known as intralesional injection.

Here are some key points regarding the use of 5-FU for scar treatment and potential systemic effects:

Localized Treatment: When 5-FU is administered intralesionally, it is delivered directly into the scar tissue, which significantly limits the amount of medication that enters the systemic circulation. This localized approach helps to minimize the risk of systemic side effects.

Systemic Side Effects: While 5-FU can cause systemic side effects when used in higher doses for chemotherapy, the doses used for intralesional injections are much lower. As a result, systemic side effects are rare in this context. However, it's important to discuss any concerns with your healthcare provider, especially if you have specific health conditions or are taking other medications.

Possible Local Reactions: Local side effects at the injection site can include redness, swelling, or irritation. These are generally mild and temporary but should be monitored.

Consultation with a Specialist: It's crucial to have the procedure performed by an experienced dermatologist or healthcare provider who can assess your specific situation and ensure that the treatment is appropriate and safe for you.

If you have any specific health concerns or conditions, it’s always best to discuss them with your healthcare provider to ensure that the treatment plan is tailored to your needs and to fully understand the potential risks and benefits.

5FU has been used in combination with cortisone IIT to reduce scarring in tissue. Personally, I use it judiciously in patients who have failed most conventional treatments. I prefer to use a baseline IIT before adding 5FU in my practice.

Best,
Dr. Karamanoukian
Realself100 Surgeon