Thanks for your question. This is actually an excellent question and is related to a number of different variables. First the size and shape of the patient makes a difference as to the relative amount of fat that is injected. In other words, a small patient will clearly not accept the amount of fat that a significantly larger one will, however, in photographs, the differences in body habitus can often be misleading. Second, just because you inject a certain amount of fat does not mean that all the fat will survive, and injecting more fat actually may increase the risk of fat loss in the long run if this exceeds the environment in which the fat can be safely injected. As a result, it is likely that smaller volumes of fat will have a higher chance of overall fat survival and retention. Also, large volumes of fat that exceed the maximum space of the recipient site, I.e., the buttocks, may result in what is called necrosis, or death, and this can result in lumpiness, volume loss and cysts as well. Technique does play a role in performing large volume fat transfer. It is important that you seek a board certified plastic surgeon who is experienced in these matters. I hope this helps and have a wonderful day. Dr Kayser - Detroit