Deep smiles on the sides of the nose, prominent "marionette" ("sad") lines extending from the corners of the mouth down toward the chin, and jowls along the jaw line result in large measure from the loss of volume of the cheek pads and the downward descent of the remnant of those pads, as well as from the loss of bone from the cheeks and chin.
Since the shrinkage of the once convex and heart-shaped cheek pad and the downward migration of the shriveled triangular remnant of it plays such a contributory role to the changes just described in the mid and lower face, any restoration of the volume to the cheek area above the region of the cheek bone and below the eyes may secondarily improve the mid and lower face by lifting it a bit. This effect is usually more significant on the mid face, i.e. more improvement may be expected on the smile lines and some improvement with the sad lines. However, only slight improvement, if any, can be expected by dealing with the cheek region, which, relatively speaking, is pretty far from the jawline jowls. The pseudolift obtained by revolumizing the cheeks can have a dramatic effect in rejuvenating the mid face and under eye regions. I have found Juvederm Ultra Plus XC to be excellent for rejuvenating cheeks.
For best results, jowls can be directly treated by revolumizing the depressed areas of the jawline that form in front and in back of the jowls. Radiesse is an excellent and relatively long-lasting volumizing material for this purpose.