18 hours post Fraxel restore 1550. Have you seen anything like this open blister on my nose? Should I be concerned? (photos)

This is just a small blister that formed and will heal fine with the proper skin care.  I am unsure why you're eyes weren't treated though based on your pictures. I suggest going to an expert for treatment.  Best, Dr. Emer.

It appears that you have a small more on your nose.  I would leave a message for the physician since you may need special creams for wound care such as Silvadene cream.  Please keep us posted.  Best, Dr. Green

This is caused by either too many passes (overtreatment) or bulk heating (passes too close together without allowing the skin to cool). The skin now needs to be treated with different would care until it heals over. See you doctor for recommendations.