If taking Accutane twice a day (1x morning, 1x night), what would be the best times of the day to take them?

it doesnt matter the time of day the half life is numerous days so when you take it per day doesnt matter.

All of my accutane/isotretinoin/acne patients do our accutane protocol and peels like aerify/cosmelan/enlighten.

Acne requires a combination approach to get long term improvement.  For all patients on isotretinoin, we require them to be on skin care such as vitamin C (Skinceuticals Phloretin CF, EmerageSkin AOX-C), glycolic cream (jan Marini bioclear, EmerageSkin enzymatic polish) , kojic acid serums (Skinceuticals phytoplus) and hyaluronic acid serum (IS clinical hydra cool serum, Skinceuticals B5, EmerageSkin hyla B) in the morning and retinols (reve skin 1.0 and sente biocomplete serum) and salicylic acid (reveskin acne purifying enhancer), growth factors and peptides (anetageMD, EmerageSkin Re-Fit Face/Eye) night.   

All of our patients get clear+brilliant non ablative laser along with a microsecond YAG laser such as aerolase or laser genesis and microneedling with PRP or microneelding RF like intensif or fractora monthly to help improve breakouts, speed the healing process, and improve scarring and facial redness while on the isotretinoin/accutane.  LED light therapy, cosmelan/enlighten/AERIFY peels, salt facial or dermalinfusion can be done as well to speed up the improvement. I suggest tyou go to an expert who combines skin care, lasers, microneedling, PRP, and facials while on oral medications for acne.  Best, Dr. Emer.

Thanks for your question. I would call your dermatologist and see if they have any specific recommendations for you. In my practice, we have patients take both capsules at the same time and don't have patients split them into two different times a day. We do recommend taking the medication with fat - such as avocado, oils, bacon, cheese, etc. which helps the absorption of the medication and helps it to be up to 40% more effective over the 6 month course. I would recommend checking with your prescriber to be sure, but we don't feel it makes any difference in outcome whether you take it at a certain time. Take care!

Thank you for your question. Accutane needs to be taken with a high calorie / high fat meal for maximum absorption, unless you are taking the medication Absorica. So in my experience, the medication should be taken with your largest and high calorie meal. I highly recommend you consult with your prescribing dermatologist regarding any further questions. Take care and good luck.