As the principal investigator for the FDA trials on Kybella, and with over 400 treatments performed, we found that Kybella injections result in significant improvement in the appearance of convexity or fullness associated with submental fat. In these clinical trials, patients did not wear a compression garment, and some patients did experience some swelling. The amount of swelling is directly related to the amount of fat present and the amount of kybella injected. In other words, if you have a large amount of fat under your chin, you would require a greater amount of kybella to treat the area effectively, and the greater the subsequent inflammatory response with swelling. I currently recommend that patients wear a compression garment for a few days to help with the post-procedure swelling. The procedure is very well tolerated by patients, fast, and can be performed in clinic. Prior to any intervention, however, a proper physical exam is necessary. I recommend visiting a board-certified facial plastic surgeon who is experienced with Kybella injections.