Is it fine if I use benzoyl peroxide in the morning and night while I’m on Accutane?

Accutane is a go-to medication for patients with recalcitrant cystic acne. It can reduce pore size and also reduce sebum production in your skin, making it less oily; and in turn, dryer. Accutane can be used to control acne, but patients receiving the medication should be carefully monitored. In terms of skincare, always wear an appropriate sunscreen and reduce direct sun exposure. In my patients, I recommend a good ceramide moisturizer such as Elevase whenever they are on Accutane. This will keep the skin hydrated and reduce the oiliness of the skin that is associated with oil-based moisturizers.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Thank you for your question. A side effect of Accutane is skin sensitivity, and a side effect of benzoyl peroxide is redness or irritation. Using benzoyl peroxide could cause more irritation and redness, which can lead to scarring, so in my opinion, Accutane should be a solo therapy.  I highly recommend you consult with your prescribing physician regarding your concerns. Take care and good luck.