Deep nasolabial folds can be a result of several factors, including aging, genetics, and lifestyle habits. While weight loss can impact the overall fullness of the face, it might not specifically target the deepening of nasolabial folds. Here are few treatment options: 1. Dermal Fillers: These are often the first line of treatment for nasolabial folds. They can help to add volume and reduce the appearance of these lines. Hyaluronic acid fillers such as Juvederm and Restylane are commonly used. 2. Fat Transfer: If you've had a conservative fat transfer in the past, you could consider another one specifically to the nasolabial fold area. This would involve harvesting fat from one area of the body and injecting it into the folds to add volume. 3. Facial Exercises: Some individuals find that facial exercises targeting the cheek and mouth area can help to reduce the appearance of nasolabial folds. 4. Topical Retinoids: These can help to stimulate collagen production in the skin, which can in turn help to reduce the appearance of nasolabial folds. 5. Laser Treatment: This can stimulate collagen and elastin production, helping to reduce the appearance of the folds. 6. Surgery: In severe cases, surgical procedures such as a facelift or cheek lift can help. It's important to consult with a board-certified dermatologist or plastic surgeon to discuss these options and decide on the best treatment plan for you. Please remember that everyone's face is unique and what works best for one person may not work as well for another.