In the clinical study, taking Tylenol or 600mg of Ibuprofen one hour before and 4-6 hours after Kybella injections was the only measure that significantly reduced pain and discomfort. In our practice, we offer topical anesthetics, anesthetic blocks, and a special icing protocol that has been met with high patient satisfaction, most patients reporting only mild discomfort during the procedure. Every patient is different and has a different pain threshold, so we customize the comfort measures to each individual patient. We believe that elevating the head and icing 6-24 hours after the procedure is helpful. Avoiding salt and alcohol can also minimize retention of fluid. It is important to remember that the swelling is a sign of the inflammatory response that removes the fat cells after they have been destroyed. Because the swelling plays a role in retraction and enhancing your profile, we tell our patients "Call me if you don't swell!" The swelling is a sign that the Kybella is working as expected! In our experience, Kybella works EVERY time.