Is it possible that Botox simply does not work on some people?

Some people may not see the results they want with Botox.
This maybe an issue with dosage. Some people have stronger muscles and require
higher dosages.In some cases, individuals may experience the changes they
want with Dysport. Dysport has fewer proteins around the main molecule.
Therefore it is not as likely to be rejected by the immune system. The
molecules of Botox and Dysport work to block the release of acetylcholine.
Without this input, the muscles will stay relaxed. Both injections are intended
to reduce dynamic wrinkles which appear when your face moves. Static fine lines
may have developed over the years due to repeated muscle contractions. These
can be addressed with a very precise filler called Belotero. Botox and Dysport
cannot eliminate tiny surface creases.

There are a small number of patients in whom Botox does not work due to immunoresistance. This is exceedingly rare. I would recommend following up with your surgeon to review the results.

When Botox was first purified, there were a larger number of patients on which it did not work (immunoresistance). With the current batch, it is exceedingly rare to have true immunoresistance to it. Far more likely are inadequate dosing, or improper storage/handling. As a patient from a troubleshooting perspective, follow up with the leading plastic surgeon and let him/her know the results. He/she may then add more units. If this still fails to show any response, then you may want to try Dysport or Xeomin. Dysport and Xeomin have different accessory proteins (Xeomin does not have any) and so even if you are immunoresistant to Botox, you should show a response.

In some patients, Botox doesn't seem to work though these patients are very rare. Generally, a larger bulk of muscle requiring more Botox, inappropriate injection, or inadequate dilution (cheap botox) can lead to decrease effectiveness. Some individuals develop an antibody to botox after their first treatment so each successive treatment doesn't work. Best option is to talk to your plastic surgeon and discuss other options such as Xeomin, Dysport, or a browlift to interrupt muscle movement.

There are some people who get no response from Botox treatments. These are people that somehow have developed a natural resistance to the toxin in Botox. It is very rare to have this issue occur, but I have seen it a few times. It is possible that if you have never had Botox work on you that you could be one of these people, unfortunately.