Botox & Dysport No Longer Working as Well, Suggestions?

If you are finding that the glabellar muscles between the eyebrows or the crows feet muscles are not being as relaxed with the same number of units of Botox or Dysport, that is not the same as finding that the forehead muscle is drooping more or the upper eyelids are sagging.  If it is the former, then you might be developing some resistance to the injections but this is extremely rare. Changing from them to Xeomin may not make a difference as all three are seropyte A botulinum toxin. As we age, the forehead sags more and what we could have done for the horizontal creases when younger can no longer be done later because the forehead sags and brings down the upper eyelids. 

It may be that you need to switch to a different neuromodulator. Two others that may be effective for you are Juveau and Xeomin. Though neuromodulators all work similarly, there are slight differences to each product that may give you the result that you are wanting.

Yes, although not very common, it is possible to develop resistance to Botox and Dysport,usually through your body making antibodies to the Botox. In those cases Xeomin  may still work and you might want to switch. Also be aware that the expertise of the injector and the number of units injected are also variables that may account for decreased response.Dysport, Xeomin and Botox are all preparations of botulinum toxin A derived protein that works at the nerve-muscle interface to relax targeted muscles. Each preparation is slightly different, for example the protein size differs. Dysport and Xeomin have been around in Europe for a long time and more recently introduced in the USA. Note the dosage is not the same between the drugs though each works well in my experience.