7 days after starting, I have a really hot and irritated skin and my cheeks are very uneven. Is this normal? Will it go away?

Doctors often refer to the dryness that occurs with isotretinoin and retinoids like Retin-A as the retinoid reaction. Although normal, the dryness can lead to a feeling of discomfort that can ultimately compromise your compliance. Retinoid reaction includes:
DrynessRednessItchingBurningDiscomfortIn my office in Beverly Hills, I prescribe Accutane quite a bit for cystic acne and inflammatory scarring. Patients are advised to moisturize frequently with a non-oily moisturizer such as Elevase Moisture Booster, which we use in our office. Applied liberally on the face, the ceramides are soothing and relieve discomfort when possible. 
Best, 
Dr. Karamanoukian
Realself100 Surgeon

Hello and thank you for your question. Some of the common side effects of Accutane is acne flare, dryness of skin, and sensitivity to sun. It is difficult to adequately assess your skin from this time of forum. So I recommend consulting with a board certified dermatologist for evaluation of your skin and discussion of appropriate treatment. Best of luck.