My breasts are a 46 DDD. I've had breasts from the 2nd grade. I weigh 220. Am I a candidate for the surgery? (Photo)

You are a good candidate for breast reduction surgery as long as you do not have any untreated medical conditions like hypertension or diabetes.  Some weight loss prior to surgery would help optimize your results. 

You should expect significant improvement in comfort after breast reduction. This should also assist in subsequent weight loss because of increased activity.