Is the collagen reduction found with the use of Minoxidil related to premature skin aging? (Oral Minoxidil)

In my country, it's not uncommon for oral minoxidil to be prescribed to battle MPB. Daily dosages range from 1 to up 3-4mg. There are a lot of studies that discuss how Minoxidil can affect collagen production, especially when it comes to lysyl hydroxylase formation. Is lysyl hydroxylase a very important collagen precursor for skin health? Are these dosages significant enough to cause premature skin aging with the inhibitory effects of chronic oral (therefore, systemic) minoxidil administration?