All-on-4, acrylic or or zirconia porcelain?

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There are two good options for prosthesis after All-on-4 implant placement. Both prosthetic options has its own advantages and disadvantages. It's better the clinician takes the final call on what is suitable for you.
Acrylic wrap around is very lighter and cosmetically appealing too, but it wears out slowly over a period of 5-10 years and needs only the acrylic part replacement, which isn't expensive at all. The titanium framework inside doesn't need replacement. People with poor bone quality, shorter implants and very elderly, I personally suggest acrylic hybrid as an option.
Zirconium porcelain prosthesis is definitely stronger and long lasting. They look natural too, but they are heavier, ceramic chip-offs do happen and it can also cause wearing-off of the opposing natural teeth or acrylic teeth many a times.But my personal suggestion is that for people who are more concerned about aesthetics and also younger age group should opt for this Zirconium Ceramic option.

The hybrid zirconia and acrylic prostheses actually have the following difference: zirconia prostheses are characterized by being the most resistant and aesthetic prosthesis material, however acrylic prostheses are also aesthetic and resistant but not the same as a prosthesis in zirconia
I can tell you that I have received patients in my practice with prostheses on hybrid acrylic implants that have been in the mouth for more than 20 years and are very well, but there are patients who have zirconia prostheses and do not last for 10 years due to lack of dental hygiene. 
The two treatments are very good and I recommend them both, but I also recommend the patient a maintenance with the dentist every 6 months. 

Choosing between zirconia or acrylic is not something patients can decide on their own. You should consult your prosthetic specialist. A prosthodontist , understands the material behavior and suitability in your situation.
Acrylic is preferred :
1. When bone loss is more, cheeks and lips are unsupported, wrinkles and folds are present, and prosthesis is required to provide support. 2. Acrylic has an advantage that additional material can be added with no risk of adding weight to the prosthesis, which is the case with crown. 
3. Acrylic can act as a cheek or lip implant in itself if your dentist feels the need to support your lips and cheeks4. Esthetics and looks : Although zirconia and ceramic look better in comparison to acrylic but new age acrylics with cross linked polymers have better strength and match nearly same esthetics.
5. Acrylic is also easy on teeth, doesn't wear the opposite teeth, unlike zirconia or ceramic. 6. If you already have ceramic or zirconia in your opposing jaw it's advisable that same or similar material be chosen.7. If you have less space (8-10mm)in each of your jaws for jaws it's better to use zirconia or ceramic as acrylic gets weak and can crack in thin sections( for acrylic minimum 12-14mm is needed).8. If your opposing dentition has denture in that case also it is advisable to go for a hybrid acrylic full fixed prosthesis. 9. Latest innovation is, one of the lightest material, PEEK polymer which is absolutely easy on opposite dentition.10.Repairing acrylic is easier. It's easy to achieve esthetics and it's durable than ceramic repair on titanium or zirconia framework11 . Average life is 7-10 years for acrylic and  zirconia framework.

There are other options on the market as science has advanced over time. I would say the best option is a new material called Xircon-Ultra it is a nano-ceramic that is light-weight, durable, and the most realistic looking. It is non-porous and does not absorb odors or discolor. The teeth actually act as shock absorbers and there are no titanium bars required. Next, would be Zirconia it is quite a bit heavier than the nano-ceramic Also, some patients complain that the Zirconia can sound like two coffee cups “clinking.”
Acrylic options have been on the market the longest and have the highest breakage rate. Acrylic typically stains easily and can also absorb odors because of its porous material. 

There are two basic options: acrylic and zirconium. 
ACRYLIC
Pros: This material looks great, it is the "tried & true" method, it can be repaired easily.
Cons: Teeth wear down over time (7-10 years) and have to be replaced, Sometimes the teeth break completely in cases where the patient is a teeth grinder. 
ZIRCONIUM
Pros: Very strong material and does not generally break or chip if made properly. This material can last you longer than 10 years if properly maintained. 
Cons: If it is made incorrectly, the whole appliance can break and it is impossible to repair it. Any small inaccuracies in the fabrication of the prosthesis can be problematic. Also, this material can look a little bit too white. (Porcelain can be added to it to give it a better cosmetic appearance but this increases the cost)

There are many options for the restorationZirconia - This is the ultimate option where there is a combination of strength and cosmetics. Most patients feel that this is the option that is the closest to the feel of their natural teeth. The material is very rigid and if upper and lower jaw is being done it is recommended to use a material that is not so rigid in the lower jaw.It has been around for approximately 10 years or so. This means the follow up is not as long as other options. Acrylic Titanium - This option does have long term follow up, the advantage of this option is that it is easily repaired should you sustain trauma to the teeth. It has some resiliency meaning that with impact the force is not at easily transferred to the implants. It does stain over a period of time but this can be cleaned and polished readilyFor a full mouth solution a combination of materials is recommended to have the esthetics of zirconia and the resiliency of acrylic titanium .

Acrylic is generally cheaper and lighter, but won't last as long as zirconia and will not look as realistic. So, if money is not the driving force in the decision, then Zirconia is the way to go. "Lifetime" is a tough expectation to put on the longevity of any dentistry because materials aren't indestructible. It also depends on the bite that the all-on-4 is set to. If it's a proper, neuromuscular bite, then there's less stress on the arch, but there are also things like your eating habits, proper care of the dentures and implants, regular hygiene appointments, etc that will all affect how long the dentures last. Zirconia ultimately will last longer because it's a stronger material. Also, depending on the restoration such as a denture or bridge, even though the technique is called 'All-On-4', you will likely need more than 4 implants if you opt for Zirconia because it's a heavier material and will require more support.

Your question is a great one!One of the biggest factors in determining which type of teeth would be best for you is to know what the opposing arch has. If you're All on 4 prosthesis will be opposing acrylic denture teeth, then you should go with acrylic teeth.If however you're posing arch has porcelain or zirconia, then you should go with a zirconia All on 4 prosthesis because it will wear much better.I hope you found this information to be helpful,Dr. Champagne

As with any medical/dental procedure, there are pros versus cons for ANY treatment, by ANY clinician. Every option has a "lifespan" or "shelf-life" for how long the restoration should last. Ultimately, the longevity of the restoration heavily relies on patient factors (i.e., genetics, overall systemic health longterm, cleaning recall frequency, home hygiene, clenching/grinding of teeth, smoking, etc. etc.). Prosthodontic care for missing teeth should be thought of in a “chronic condition” context.  You must recognize that long-term outcome monitoring is necessary.Think of a prosthetic arm or leg: As with any other body part that needs to be replaced as a result of an amputation, there is maintenance!The overall goal of the All-on-4 (Fixed bridge implant bridge) protocol is to restore a terminal or missing dentition. The dentist/dental specialist restoring the case is giving you a tooth substitute (not replacement).  Since we cannot implant natural teeth, the two most common substitutes are: 1. Acrylic  or 2. Zirconia. A combination that is used more and more is an upper zirconia bridge opposing a lower acrylic bridge. I've seen some patients that come in for second opinions that have very PRETTY Acrylic bridges, but also some with very UGLY Acrylic bridges. Zirconia bridges are the same, some are very esthetic, others are VERY OPAQUE, dead looking, and can look "Less-natural" than an Acrylic bridge. Ask your dentist to show you some ORIGINAL work, not stock photos.Each have its pros and cons:ACRYLIC: Description: Typically a titanium milled (CAD/CAM) bar connects the four implants. Acrylic denture teeth are set on the bar, tried in for approval of esthetics, and the teeth are processed (connected to the bar) with a pink acrylic. So in essence, there is 3 layers: the bar, the teeth, and the pink acrylic that connects everything. There needs to be necessary room for all layers (14-16mm), otherwise the bridge will not fit in the space provided.  Many times repairs/breaks on the acrylic hybrid All-on-4 bridge are a result of the minimized space; either the teeth or the acrylic has to be thinned out, weakening the strength. PROS: Cost is Less (denture teeth come  "stock," mass-fabricated)Easier to repair Acrylic is softer, so there is a "give" to the bite, for grinders they will slowly wear away the acrylic, similar to natural teeth. However, if the material is more stiff (Ceramic) a grinder can chip the restoration (too brittle). CONS: Staining more frequentDelamination (Debonding) of tooth from acrylicWear is fasterHigher repair; in a study in the Journal of Prosthodontics, 255 patients were followed up for an average of 13 years, and approximately 58% had one or more prosthetic events (i.e, chipped/broken tooth, loose implants screw) during that recall period.  Overall survival rates at 20 years were 86% for prostheses (bridge), 15% survived free of any event, and 92% experienced survival free of biological implant failure. ZIRCONIA:Description: A monolithic, high-strength material that is directly fitted to the 4 implants (without a titanium bar). PROS:Zirconia is Harder than Acrylic (for grinders they will slowly wear away the zirconia compared to acrylic)Can layer porcelain for more esthetic, natural look (should be as minimal layering as possible)No chance for tooth delamination/debonding (All one piece)Can be used in limited space situations (12-16 mm of space)CONS: Cost is Higher (requires expensive milling/sintering machinery, custom hand finishing/detailing)Very Opaque (porcelain can be layered, or added to improve esthetics, but the porcelain can chip)Harder to repair (since the material is all one piece, if a "chip" occurs, the entire bridge needs to be replaced, OR a ceramic veneer can be glued to the front surface of the bridge as an alternative)Too Stiff (because of the incredibly stiff nature of the zirconia there is a potential for catastrophic failure from fracture of the entire zirconia bridge)As with all comments, ask a professional Prosthodontist in your area what treatment best suites your needs.