Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. Yes, Juvederm Ultra Plus can be used in the lips, and it does tend to provide more volume than regular Juvederm Ultra. Both products are hyaluronic acid-based dermal fillers, but Juvederm Ultra Plus has a thicker, more robust formulation compared to regular Ultra. This makes Ultra Plus ideal for areas that require more volume and support, like the lips, especially if you're looking for a more pronounced or plump result. Juvederm Ultra is often used for subtle lip enhancement, where a more natural or soft volume increase is desired. In contrast, Juvederm Ultra Plus is typically used when a more noticeable, volumizing effect is preferred. It’s also a good choice for patients who have slightly more lip volume loss or who want more definition and contour around the lip borders. In terms of the difference in results, Ultra Plus can create a fuller, more defined appearance with fewer injections, as its thicker consistency allows it to stay in place longer and provide more lift. However, it's essential to consider that because of its thicker texture, Ultra Plus might also have a slightly higher chance of causing swelling immediately after the injection compared to regular Ultra, but the results are typically longer-lasting. I hope this helps and best of luck!