How Does Zeltiq Coolsculpting Affect Cholesterol Levels in the Bloodstream?

Doctor Answers 13

No Change Of Cholesterol withZeltiq

Over the last 2 to 3 years the FDA has become much tougher in approving new devices. One area of particular concern for approval of the Zeltiq-cool sculpting device was: does it effect cholesterol levels. The FDA said it fortunately has no effect on cholesterol levels. Of coarse, with all new technologies doctors and patients should remain vigilant for any u expected untoward responses.

Long Island Dermatologic Surgeon
5.0 out of 5 stars 17 reviews

Cool Sculpting doesn't increase your cholesterol even though it freezes your fat cells!

Body reshaping can be performed with a cannula that removes fat via liposuction or with noninvasive technology like Cool Sculpting. With Cool Sculpting there is no cannula inserted into your body. All treatments are performed on the surface from the outside in using technology that freezes the fat. Don’t hesitate to give us a call in Austin regarding a Body Reshaping Consult at the Upper Room. On our Facebook Page there is an Interview I recently did with KVUE, a local news station in Austin, that was picked by affiliates around the United States, including Miami. During the Interview we discussed the technology of Cool Sculpting as well as it application process.

CoolSculpting does not affect cholesterol levels

This was taken straight from the CoolSculpting website:

A multi-site study examined the effect of Cryolipolysis® on serum lipids (cholesterol, triglycerides, etc.) and liver function test results and showed:

  • No damage to overlying skin or surrounding structures confirmed by clinical observation.
  • No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12-week follow-up period.

Coolsculpting does not affect blood cholesterol levels

Several have been done proving that Coolsculpting does not raise or lower blood lipid levels.  This includes cholesterol and triglycerides.

Cholesterol after Zeltiq

Multiple studies have ascertained that blood lipids and trigleryides are not affected following non surgical fat reduction like Zeltiq and LipoSonix. Todays clinical trials have confirmed that blood cholesterol lipids as well as triglycerides are not affected through any of the FDA approved non-surgical fat reduction procedures.

Cameron Rokhsar, MD, FAAD
New York Dermatologic Surgeon
4.5 out of 5 stars 34 reviews

No elevation of blood cholesterol or triglycerides with CoolSculpting

The safety of CoolSculpting was shown by Zeltiq during its applcation for clearance of their device.  No elevation of circulating fats as the fat cells are killed and then gradually metabolized over a couple of months.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
5.0 out of 5 stars 38 reviews

CoolSculpting and Cholesterol Levels

Thank you for your question.  Zeltiq performed years of clinical trials and obtained FDA clearance for this machine.  With the gradual removal of the fat cells during an 8 week period (or more), it has not been found that the cholesterol level of patients is increased by having this procedure performed.  

Best Wishes!

CoolSculpting and effect on cholesterol levels...

Great question.  This was one of the major factors that the FDA looked at before clearing this device for use.  There has been no detectable increase in the level of cholesterol in the bloodstream of patients in the research studies to date.

Lori Stetler, MD
Dallas Dermatologic Surgeon
4.5 out of 5 stars 9 reviews

No change in Cholesterol levels with CoolSculpting by Zeltiq

Because fat cells are destroyed via cold injury, and then removed gradually over a period of eight weeks or more, all blood testing has revealed no rise in the cholesterol levels after the CoolSculpting procedure.

Coolsculpting Does not Affect Cholesterol Levels


To date, the studies have shown that the slow reduction of fat after Coolsculpting does not raise the cholesterol in your blood or affect your cardiovascular system adversely.  The company is very stringent in their clinical studies and safety studies before it obtained FDA approval.


Dr. Liu

Grace Liu, MD
Newport Beach Dermatologic Surgeon
5.0 out of 5 stars 43 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.