Is it safe for me to get PRP injections under my eyes if I have ulcerative colitis and just started Vedolizumab infusions?

For anyone with a chronic or autoimmune health condition, there will likely be concerns about new treatments, and whether they have side effects. People who should NOT have PRP include people with current low platelet counts, people with metastatic disease, people with an active infection, breastfeeding women or pregnant women.
However, in the hands of a competent medical practitioner, PRP is considered safe as it uses the body’s own growth factors, spun through a centrifuge which are then reinjected to the area of treatment. Traditionally, PRP has been used successfully for conditions such as tennis elbow and plantar fasciitis, but recent research shows that it may assist with everything from incontinence and hair thinning through to the auto-immune condition Lichen Sclerosus. In 2020, PRP was also used in a preliminary trial on another auto-immune disorder inflammatory bowel disease and found to be feasible, safe and promising. A further 2020 study in Case Reports Rheumatology shows that PRP may also be beneficial in other immune-mediated disorders such as rheumatoid arthritis. None of the people in the studies had an adverse reaction to PRP. So, if you are having PRP injections for your eyes, I hope this provides some reassurance.
Other options you may wish to consider include Botulinum Toxin, dermal fillers such as hyaluronic acid and skin-tightening procedures Disclaimer: All results are individual. All procedures have risks. Speak to your doctor about your symptoms.

PRP is typically safe, the efficacy of the PRP is what we don't have a great grasp on in patients that are on disease modifying medications (DMARDS). It won't cause any type of flare up of your UC from getting PRP, but your Plt counts and growth factors might be impacted. Research is still ongoing in terms of people on DMARDS medications and PRP. But it won't hurt you to get PRP injections. 

All good as PRP is derived from your own blood. The treatment of dark circles should be directed at the cause- eg. constitutional vs dermatitis vs anatomical etc.. in some case fillers can be beneficial, in other cases topical skin care. Dr Davin S. Lim. Brisbane. Australia.