What is a unit? How many units are in a Botox bottle?
What is a Botox Unit?
Doctor Answers 11
A Botox unit is essentially a measure of a defined amount of biological activity and corresponds to a fixed number of botulinum toxin molecules. Botox typically comes in 100 unit vials. As a patient you ought to keep track of how many units were injected in which locations.
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There are 100 units in a botox vial.
This is an arbitrary number derived from studies in animals. There are 100 units in every Botox vial. You should ask your doctor to see the bottle (look for the authentic hologram) and ask how fresh the Botox is. Always make sure the price is by the unit, not the cc.
How is a Botox unit is measured & why authentic Botox is important
Standard dosing ranges of Botox units to treat certain regions of the face have been published in the medical literature. The measurement of the Botox unit is done in the the manufacturer's (Allergan) lab on each batch of Botox; a unit measures the biologic activity of the Botox so the strength can be kept within a narrow, uniform range.
That is why the FDA recommends that practitioners use Botox Cosmetic purchased from Allergan within the USA. The bottle comes with a hologram for verification of the authenticity of production.
A Unit of BOTOX is a measure of biological effect
One unit of BOTOX refers to the biological activity of this medication which is a neuromuscular toxin. The toxin is taken up at the terminus of of the nerve that is responsible for stimulating muscle contraction. The effect of the toxin is the prevention of acetylcholine release at the nerve terminus, preventing muscle contraction. The effect of BOTOX is temporary because the nerve eventually replaces the block terminus.
The definition of a unit the amount of BOTOX that when injected into a 18-20 gram Swiss-Webster female mouse is lethal for 50% of the animals. Currently each lot of BOTOX is tested in this fashion to assure the safety of the product. Animal advocates have challenged Allergan, the maker of BOTOX, to use an assay for the product that does not involve animals dying from respiratory arrest. There is a leg paralysis test that could be used. The difficulty is that as you can imagine, the testing of BOTOX is what ensures the safety of BOTOX. The track record of this product is impeccable. The FDA has approved and vetted the safety of BOTOX based on this testing method. Therefore, changing the testing of the drug would require the approval of the FDA and this is improbable.
Now although one unit of Botox is obviously very dangerous if you are an 18 gram mouse, the amount of BOTOX used for a cosmetic service does not appear to associated with systemic side effect. On the other hand, the FDA is now requiring a new warning for the use of Dysport and BOTOX that these treatments in high enough dose can be assoicated with systemic side effects. The systemic side effects appear to only be associated with the very high doses used to treat medical conditions like cervical dystonia and muscle spasm seen in children with cerebral palsy.
Allergan packages BOTOX in the United States market with 100 units of BOTOX. Dysport is now approved for the United States market. It is also a botulinum toxin A. However it is packaged in vials of 300 and 500 units in the United States. These two drugs are not equivalent. While some claim that BOTOX is approximately 3 times stronger than Dysport, this formula is not precise and it takes clinical experience to determine what is the correct dosage for a give person with any of these products.
BOTOX has 100 units per vial
Botox has 100 units per vial. The effectiveness of the Botox on diminishing muscle movement is dependent on the dose of units given, not the dilution. Doctors must dilute the bottle of Botox powder with saline to make it a liquid. The doctor then knows, based on the amount of liquid added to the bottle, how many units are contained in a given volume of liquid.
It is the measurement scale and is standardized for Botox made by Allergan.
One bottle has 100 units. Typically we use 20units in the area between eyebrows called Glabella.
Remember the units are different for Dysport the newly approved Botulinum toxin launched by the company Medicis. Their bottle has 300units and typically we inject 50units in the Glabella.
Botox is measured in units
All medications have measurements that describe that amount of the active ingredient of the medication. Most medications are measured by weight (milligrams, grams, etc.). However medications that are biologically derived are measured in units which describes the amount of effect of the medication in a given lab test. Insulin for example, is measured in units, as is Botox.
The number of units of Botox you receive is the amount of Botox that you have been given. As an example, the average person usually gets about 20 units of Botox to treat the lines between their brows (this number certainly varies from person to person)
The number of Units of Botox in a bottle is usually not relevant to patients because all that matters is the amount of medication that you are receiving. Botox, most often, comes in a 100unit bottle.
Hope this is helpful.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.