Possibility of Infection from Fractional CO2 Treatment?

Is infection something to be worried about with Fractional CO2 treatment? I'd like to get a milder CO2 Fractional treatment. I've had a Fraxel Restore. I've no complaints-my skin tolerated it very well, but I am looking for more of a result for fine vertical smile lines on the sides of my face.I am thinking about a DOT Laser treatment. My only concern is of infection. I keep reading risk of bacterial or fungal infection with CO2 Fractional is high. Is that correct and can prophylactic RX for antibiotic/anti fungal eliminate the risk? I am an equestrian, live on a farm and on well water. Not a super sterile environment.